Relationship between PLR Value and Severity of Dengue Infection in Pediatric Patients in the Aster Room at RSUD dr. Soebandi Jember

Authors

  • Nicholas Jirezra Gianevan Faculty of Medicine, University of Jember, Jember, Indonesia
  • Rini Riyanti Department of Clinical Pathology, Faculty of Medicine, University of Jember, Jember, Indonesia
  • Muhammad Ali Shodikin Department of Pediatrics, Faculty of Medicine, University of Jember, Jember, Indonesia
  • Sheilla Rachmania Department of Histology, Faculty of Medicine, University of Jember, Jember, Indonesia
  • Rosita Dewi Department of Histology, Faculty of Medicine, University of Jember, Jember, Indonesia

DOI:

https://doi.org/10.19184/ams.v11i2.50026

Abstract

Dengue infection is a disease caused by dengue virus infection and transmitted by the Aedes mosquito, and is a major health problem in children, especially in developing countries. The Platelet to Lymphocyte Ratio (PLR) is a novel inflammatory biomarker that has recently been frequently studied and plays a role in the assessment of viral infectious diseases, and the use of PLR in viral infectious diseases has previously found greater potential compared with the Neutrophil-Lymphocyte Ratio (NLR). It is hoped that PLR can become a new biomarker for predicting the severity of dengue infection which is suitable for use in developing countries because PLR ​​is a cheap biomarker and is available in all clinical conditions. This research is a correlative analytical observational study using a cross-sectional approach. This research design was carried out by collecting data from children diagnosed with dengue infection as well as data on platelets and lymphocytes on the first day of admission to the hospital. This research uses stratified random sampling. Data were analyzed using Spearman correlation with a confidence level of 99%. The results of Spearman's correlation analysis showed a strong significant relationship with p<0.01 (p=0.000) and a correlation coefficient of -0.753. In conclusion, there is a significant and strong relationship between the Platelet-to-Lymphocy Ratio (PLR) value and the severity of dengue infection in pediatric patients in the Aster ward of RSUD Dr. Soebandi Jember. If the PLR ​​value increases, the severity of dengue infection will be lower or decrease and vice versa.

Keywords: PLR; dengue infection; children; platelets; lymphocytes

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References

Audia, S., Mahevas, M., Nivet, M., Ouandji, S., Ciudad, M., & Bonnotte, B. (2021). Immune Thrombocytopenia: Recent Advances in Pathogenesis and Treatments. HemaSphere, 5(6), E574. https://doi.org/10.1097/HS9.0000000000000574Cai, J. R., Camacho, I. B., Caras, E. M., Carayugan, J. A., Carmona, K. H., Castillo, C. O., Castillo, E. D., Nieto, X. A., & Sison, R. G. (2021). The Prognostic Significance of Established Hematological Parameters and Inflammatory Biomarkers in Assessing Dengue Infection Severity and Progression among Patients Ages 5 to 14 in a Tertiary Government Hospital in Pampanga, Philippines. American Journal of Clinical Pathology, 156(Supplement_1), S103–S104. https://doi.org/10.1093/ajcp/aqab191.220Chatterjee, A. B., Matti, M., & Kulkarni, V. (2020). Role of platelet parameters in dengue fever in children. Pediatric Oncall, 17(1), 12–15. https://doi.org/10.7199/ped.oncall.2020.10Fadilla, A. N., Dominicus Husada, & Budi Utomo. (2020). Epidemiology of Children with Severe Dengue Infection in Dr. Soetomo General Hospital. Journal Of The Indonesian Medical Association, 70(4), 41–47. https://doi.org/10.47830/jinma-vol.70.4-2020-220Jelia, S. C., Ajmera, D., Airan, D., Bairwa, R., & Meena, Y. (2023). Predictors of hemorrhagic manifestations in dengue: A prospective observational study from the Hadoti region of Rajasthan. Journal of Acute Disease, 12(6), 226–232. https://doi.org/10.4103/2221-6189.390384Khanam, A., Gutiérrez-Barbosa, H., Lyke, K. E., & Chua, J. V. (2022). Immune-Mediated Pathogenesis in Dengue Virus Infection. Viruses, 14(11), 1–19. https://doi.org/10.3390/v14112575Koupenova, M., Livada, A. C., & Morrell, C. N. (2022). Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity. Circulation Research, 130(2), 288–308. https://doi.org/10.1161/CIRCRESAHA.121.319821Lunghi, B., Lecchi, A., Santacroce, R., Scavone, M., Paniccia, R., Artoni, A., Gachet, C., Castaman, G., Margaglione, M., Bernardi, F., & Cattaneo, M. (2020). Severe bleeding and absent ADP-induced platelet aggregation associated with inherited combined CalDAG-GEFI and P2Y(12) deficiencies. In Haematologica(Vol. 105, Issue 7, pp. e361–e364). https://doi.org/10.3324/haematol.2019.232850Made, N., Handayani, D., Putu, D., Udiyani, C., Putu, N., & Mahayani, A. (2022). Hubungan Kadar Trombosit , Hematokrit , dan Hemoglobin dengan Derajat Demam Berdarah Dengue pada Pasien Anak Rawat Inap di BRSU Tabanan Berdasarkan data Kementrian Kesehatan Demam Berdarah Dengue dapat. Aesculapius Medical Journal, 2(2), 130–136.Propson, N. E., Roy, E. R., Litvinchuk, A., Köhl, J., & Zheng, H. (2021). Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging. Journal of Clinical Investigation, 131(1), 1–17. https://doi.org/10.1172/JCI140966Ravindra, R., Ramamurthy, P., Aslam S, S. M., Kulkarni, A., K, S., & Ramamurthy, P. S. (2022). Platelet Indices and Platelet to Lymphocyte Ratio (PLR) as Markers for Predicting COVID-19 Infection Severity. Cureus, 14(8), 4–11. https://doi.org/10.7759/cureus.28206Regita Pratiwi, Yuniati Yuniati, dan Muhammad Buchori. 2021. Hubungan usia, jenis kelamin, dan status perdarahan terhadap terjadinya komplikasi pada anak dengan infeksi dengue di rsud abdul wahab sjaharanie samarinda. Jurnal Sains Dan Kesehatan. 3(2):212–217.Setiawan, A. F., Wajib, Y. Y. P., Handono, K., & Sakti, S. P. (2023). Role of Lymphocytes and Atyphical Lymphocytes in Dengue Hemorrhagic Fever: A Literature Review. Journal of Medicinal and Chemical Sciences, 7(1), 53–58. https://doi.org/10.26655/JMCHEMSCI.2024.1.6Simadibrata, D. M., Pandhita, B. A. W., Ananta, M. E., & Tango, T. (2022). Platelet-to-lymphocyte ratio, a novel biomarker to predict the severity of COVID-19 patients: A systematic review and meta-analysis. Journal of the Intensive Care Society, 23(1), 20–26. https://doi.org/10.1177/1751143720969587Tasya, Rahmayanti, S., & Fitriangga, A. (2022). Hubungan Infeksi Dengue Dengan Rasio Trombosit dan Limfosit pada Pasien Anak di RSUD Sultan Syarif Mohamad alkadrie Tahun 2019. Majalah Kedokteran Andalas, 45(1), 1–10.Verliyanti, Esa, T., & Nurulita, A. (2023). Analysis of Platelet Lymphocyte Ratio on Severe COVID-19 and Dengue Hemorrhagic Fever Grade IV. Indonesian Journal of Clinical Pathology and Medical Laboratory, 30(1), 78–82. https://doi.org/10.24293/ijcpml.v30i1.2053Widodo, D. (2017). Buku Ajar Ilmu Penyakit Dalam. 3, 1, 549–558.Yulianto, A., Laksono, I. S., & Juffrie, M. (2017). Faktor Prognosis Derajat Keparahan Infeksi Dengue. Sari Pediatri, 18(3), 198. https://doi.org/10.14238/sp18.3.2016.198-203

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Published

2025-06-28

Issue

Vol. 11 No. 2 (2025)

Section

Original Research Articles

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Copyright (c) 2025 Nicholas Jirezra Gianevan, Rini Riyanti, Muhammad Ali Shodikin, Sheilla Rachmania, Rosita Dewi

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