The Relationship Between Antihypertensive Drug Compliance and the Incidence of Intradialyctic Hypertension in Hemodialysis Patients at RSD dr. Soebandi Jember

Abstract

Chronic renal failure is a global health problem with the number of sufferers increasing every year. This disease is classified into five stages based on glomerular filtration rate values with or without evidence of kidney damage. In the end stage of chronic renal failure, patients require renal replacement therapy, namely kidney transplantation or hemodialysis. Having hemodialysis therapy is capable cause various complication, one of them is intradialytic hypertension. One of the important thing to do to prevent intradialytic hypertension in hemodialysis patent is consuming antihypertensive drug. Antihypertensive drug is capable to control blood pressure, but the usage must be accompanied by patient compliance in consuming drug in order to provide long-term treatment effect. If the patient does not obey on consuming the drug and their blood pressure cannot be controlled the complication will exist, such as the organ damage. Therefore, the aim of this study is to determine the relationship between adherence to consuming antihypertensive drugs and intradialytic hypertension in hemodialysis patients. This study used an analytic observational method with a cross sectional approach. The sample in this study used 88 eligible respondents. The level of drug compliance was measured by using the MMAS-8 (Modified Morisky Adherence Scale) questionnaire, while the blood pressure was measured by using a tensimeter from pre-dialysis to post-dialysis. The data will be processed and analyzed by using chi-square test. Based on the result of the study obtained a p-value is <0.05 (p-value = <0.001), it can be concluded that there is a relationship between compliance with antihypertensive drug consumption with intradialytic hypertension in hemodialysis patients.

Keywords: intradialytic hypertension, medication adherence, MMAS-8 questionnaire.